. 2010 Jan 1;49(1):984–993. doi: 10.1016/j.neuroimage.2009.08.002

Table 2.

(A) Volumetric data for whole brain, left and right cerebral hemisphere, caudate, hippocampus and amygdala volumes as a percentage of total intracranial volume (TIV), (B) cortical thickness data for the frontal, temporal and parietal lobes.

A
Cerebral region volumes (as a percentage of TIV), mean (standard deviation)	SD	PNFA	LPA	GRN only	AD only	Controls
Whole brain	68.1 (3.8)	64.2 (5.7)^a,d	65.1 (5.6)^a	63.2 (0.8)	66.3 (6.3)	70.1 (4.0)
Left hemisphere	32.7 (2.0)	31.1 (2.9)^a	30.7 (3.0)^a	28.3 (0.2)^a	31.8 (2.9)^a	34.4 (1.9)
Right hemisphere	34.7 (1.8)	32.2 (2.8)^a,d	33.6 (2.8)	33.9 (0.3)	33.7 (3.4)	34.6 (2.0)
Left/right hemispheric ratio	0.94 (0.01)^a,b	0.97 (0.04)^a	0.91 (0.05)^a,f	0.83 (0.00)^a	0.94 (0.01)^a	1.00 (0.01)
Brainstem	1.26 (0.11)	1.20 (0.15)	1.22 (0.12)	1.21 (0.07)	1.23 (0.14)	1.27 (0.10)
Left caudate	0.20 (0.03)	0.19 (0.03)^a	0.19 (0.02)^a	0.19 (0.01)	0.18 (0.01)^a	0.22 (0.03)
Right caudate	0.22 (0.03)	0.20 (0.02)^a	0.22 (0.03)	0.24 (0.01)	0.20 (0.02)	0.23 (0.04)
Left hippocampus	0.13 (0.04)^a,b,c	0.20 (0.03)	0.18 (0.05)^a	0.15 (0.02)^a	0.19 (0.04)^a	0.22 (0.03)
Right hippocampus	0.21 (0.03)	0.22 (0.03)	0.22 (0.04)	0.21 (0.00)	0.22 (0.04)	0.24 (0.03)
Left amygdala	0.04 (0.02)^a,b,c	0.08 (0.01)	0.07 (0.02)^a	0.07 (0.02)	0.07 (0.02)^a	0.08 (0.01)
Right amygdala	0.07 (0.02)^a,b,c	0.08 (0.01)	0.09 (0.02)	0.11 (0.00)	0.09 (0.02)	0.09 (0.01)

B
Cortical thickness in each lobe (mm), mean (standard deviation)
Frontal	Left	2.2 (0.1)	2.0 (0.2)^a,d	1.9 (0.1)^a,e	1.9 (0.1)^a	1.9 (0.1)^a	2.2 (0.1)
Right	2.3 (0.1)	2.1 (0.1)^a,d	2.1 (0.1)^e	2.3 (0.0)	2.1 (0.1)^a	2.2 (0.1)
Temporal	Left	1.7 (0.2) ^a,b	2.1 (0.3)^a	1.8 (0.1)^a,f	1.6 (0.4)^a	1.9 (0.1)^a	2.4 (0.1)
Right	2.2 (0.2)^a	2.2 (0.2)^a	2.3 (0.1)	2.5 (0.1)	2.2 (0.1)^a	2.4 (0.1)
Parietal	Left	2.0 (0.1)	1.8 (0.2)^a,d	1.7 (0.1)^a,e	1.8 (0.1)^a	1.7 (0.1)^a	2.0 (0.1)
Right	2.1 (0.1)	1.9 (0.2)^a,d	2.0 (0.1)^e	2.2 (0.1)	1.8 (0.1)^a	2.0 (0.1)

Statistically significant differences between the SD, PNFA, LPA and control groups are represented by superscript letters: ^ap < 0.05 disease group significantly worse than controls, ^bp < 0.05 SD worse than PNFA, ^cp < 0.05 SD worse than LPA, ^dp < 0.05 PNFA worse than SD, ^ep < 0.05 LPA worse than SD, ^fp < 0.05 LPA worse than PNFA. For the LPA subgroups of GRN only and AD only a superscript letter^a represents p < 0.05 disease group significantly worse than controls.