Skip to main content
. Author manuscript; available in PMC: 2010 Sep 21.
Published in final edited form as: Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):73–78. doi: 10.1097/MED.0b013e3282f43a73

Figure 2. Postulated mechanism involving sweet (T1R) and bitter (T2R) taste receptors on enteroendocrine cells.

Figure 2

Taste receptors couple to G proteins upon activation to induce intracellular Ca2+ increase resulting in release of peptides, which regulate a variety of gastrointestinal functions, including action on organs associated with the gut like the gallbladder and pancreas, via neuronal or humoral pathways to induce digestion and absorption or protection from harmful substances. Released peptides can also control food intake through the gut–brain axis.