Figure 3.

Effect of farnesyltransferase (FTase) inhibitor, FTI-277, on H₂O₂-induced reduction in cell viability in SH-SY5Y cultured cells. SH-SY5Y cells were treated with 2.0, 5.0, and 10.0 μM FTI-277 for 3 hours prior to incubation with 0.1 mM H₂O₂ for another 24 hours. Cell viability was assessed using MTT assay and presented as percentage of untreated (0 mM) control cells. The results are expressed as mean ± SEM of four independent experiments. The ANOVA was performed for statistical analysis (*P <.05 compared with control and ^#P <.05 compared with H₂O₂-treated cells).