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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Biochem Pharmacol. 2010 Jun 26;80(8):1125–1132. doi: 10.1016/j.bcp.2010.06.031

Fig. 3.

Fig. 3

Kinetic analysis of the inhibition of rat pol β by PGG. (A and B) Lineweaver–Burk double-reciprocal plots obtained by varying DNA template-primer (i.e., poly(dA)/oligo(dT)18) concentrations (A), and dNTP substrate (i.e., dTTP) concentrations (B). (C and D) The inhibition constant (Ki) were determined as 20.1 and 23.8 nM from a Dixon plot made on the basis of the same data for A and B, respectively. The amount of pol β in the assay mixture was 0.05 unit.