Table 1.
VTE Risk Factor Levels by Total TFPI Quartiles, LITE
| Quartiles (Controls Only) |
p for trend | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| N | 262 | 271 | 265 | 237 | |
| TFPI (ng/mL, range) | 22.3 (7.1, 27.4) | 30.9 (27.5, 34.0) | 37.5 (34.1, 41.9) | 51 (42.0, 91.5) | |
| Demographics | |||||
| Age (years, SD) | 59.9 (9.9) | 62.2 (10.1) | 63.6 (9.8) | 64.0 (9.9) | <0.001 |
| Black Race (n, %)* | 94 (25) | 110 (29) | 96 (26) | 100 (27) | 0.56 |
| Female Sex (n, %)* | 246 (66) | 200 (54) | 198 (53) | 197 (53) | 0.003 |
| Physiologic Characteristics | |||||
| BMI (SD) | 27.3 (4.9) | 28.0 (4.9) | 28.6 (6.0) | 27.9 (5.1) | 0.05 |
| Diabetes (n, %)* | 30 (8) | 43 (12) | 63 (17) | 60 (16) | 0.01 |
| Coronary Heart Disease (n, %) | 16 (4) | 42 (11) | 37 (10) | 33 (9) | 0.004 |
| Genetic Risk Factors | |||||
| Factor V Leiden (n, %)* | 21 (6) | 17 (5) | 20 (6) | 15 (4) | 0.71 |
| Prothrombin 20210A (n, %)* | 8 (2) | 9 (2) | 7 (2) | 10 (3) | 0.89 |
| Biomarkers | |||||
| Factor VII (%, SD) | 120 (30) | 116 (27) | 123 (29) | 125 (28) | <0.001 |
| Factor VIII (%, SD) | 124 (36) | 131 (38) | 135 (43) | 138 (47) | <0.001 |
| Factor IX (%, SD) | 136 (31) | 141 (30) | 147 (31) | 155 (31) | <0.001 |
| Factor XI (% SD) | 126 (32) | 128 (33) | 135 (35) | 144 (34) | <0.001 |
| D-dimer (ug/mL, SD) | 0.51 (0.53) | 0.51 (0.43) | 0.61 (0.53) | 0.65 (0.58) | <0.001 |
*
p-value for χ2 test, other p-values from ANOVA