. Author manuscript; available in PMC: 2010 Dec 10.

Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7689–7705. doi: 10.1021/jm900695w

Table 3.

Enzyme inhibitory and antiviral activity of E and Z isomers of 14a-c

Ring size	K_i (nM)	IC₅₀ (nM)^a
15	0.24 ± 0.07	360
15	0.16 ± 0.04	>1000
14	0.18 ± 0.01	6.6
14	0.9 ± 0.3	2.9
13	0.06 ± 0.01	7
13	0.012 ± 0.004	4.6

MT-2 human T-lymphoid cells exposed to HIV-1_LAI; Saquinavir and amprenavir exhibited IC₅₀ values of 16 nM and 27 nM, respectively.