Examples of evolutionary breakpoint regions (EBRs). Ferungulate- artiodactyl- and primate-specific EBRs on HSA1 at 175-247 Mbp (other lineage-specific EBRs not shown). Homologous synteny blocks constructed for the macaque, chimp, cattle, dog, mouse, rat and pig genomes were used for pair-wise comparisons (4). White areas correspond to EBRs. Arrows to the right of the chromosome ideogram indicate positions of representative cattle-specific, artiodactyl-specific (specific to the chromosomes of pigs and cattle), ferungulate-specific (cattle, dog and pig), primate-specific (human, macaque, chimp), and hominoid-specific (human and chimp) rearrangements. Opossum is shown as an outgroup to the eutherian clade, which allows classification of ferungulate-specific EBRs.