Fig. 4.
Age-associated changes in arterial function in humans. (A) Flow-mediated induced dilation in the brachial artery of apparently healthy women. (Adapted from Celermajer DS, Sorensen KE, Spiegelhalter DJ, et al. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994;24(2):471–6; with permission.) Age-associated increase in carotid-femoral PWV (B), an index of central arterial stiffness, and in augmentation index (C) in healthy men (red) and women (blue). Best-fitting age regression curves are shown for men (solid lines) and women (dashed lines).