Skip to main content
. 2010 Jul 23;285(39):30069–30078. doi: 10.1074/jbc.M110.148288

FIGURE 5.

FIGURE 5.

FGFR4-dependent apoptotic cell death increases with increasing KLB expression and is stimulated by either FGF19 or FGF1. A, transient expression of KLB in FGFR4-expressing cells. 293 cells harboring inducible FGFR4 cDNA were transiently transfected (tKLB) overnight by the amount of KLB-pEF1a in μg/ml indicated in parentheses. FGFR4 was then induced by the addition of 10 ng/ml of Tet for 24 h followed by analysis of apoptosis and expression. B and C, stimulation of KLB-FGFR4-induced apoptosis by either FGF19 or FGF1. FGF19 (B) or FGF1 (C) was added at the concentrations in ng/ml indicated in parentheses to cells co-expressing constitutive KLB and FGFR4 induced by 10 ng/ml Tet.