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. 2010 Jul 14;285(39):30139–30149. doi: 10.1074/jbc.M110.145698

FIGURE 3.

FIGURE 3.

Inverse expression of il-13 and let-7a suggests a functional association. A, the let-7a target sequence in the il-13 3′-UTR is conserved across mammalia (Targetscan 5.1). B, mature let-7a sequence (green) aligned with the mouse il-13 3′-UTR target site (red) and predicted minimum free energy (mfe) value. The let-7a seed sequence is shown. C and D, quantitative RT-PCR analysis of il-13 and ifn-γ (C) and mmu-let-7a (D) transcripts from in vitro cultured Th1 and Th2 cells. Data are presented as means ± S.E. (error bars), n = 3; *, p < 0.05.