FIGURE 1.

Adenylyl cyclase activity of membranes prepared from striata of Gng7^−/− mice (KO) and wild-type littermates (WT), expressed as pmol of cAMP per mg of membrane protein per min. A, adenylyl cyclase activity in response to no added agonist (None), 1 μm GTP alone (GTP), or with 10 μm CGS-21680 (CGS) or 25 μm CGS-21680. B, in response to 100 μm forskolin (Forsk), adenylyl cyclase activity is significantly reduced in Gng7^−/− striatal membranes (n = 9 mice in each group, *, p < 0.01 by Student's t-test).