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Natriuretic in vivo activity of BR-4628 and spironolactone in conscious rats. The increase of the urinary sodium to potassium ratio after oral application of vehicle (V), BR-4628 (1 and 10 mg/kg), and spironolactone (1 and 10 mg/kg) was determined by flame spectroscopy of urine samples after a collection period of 8 h. Each bar represents the mean value of n = 8 animals ± S.E. *, p < 0.05; **, p < 0.01; and ***, p < 0.005 versus vehicle after calculation using Student's t test.
