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. 2010 Jul 23;285(39):30034–30041. doi: 10.1074/jbc.M110.151209

FIGURE 4.

FIGURE 4.

LSD1 regulates H3K4 and H3K9 methylation at the cebpa promoter. A, ChIP assays show that lsd1 knockdown results in decreased H3K4 dimethylation (left panel) and increased H3K9 dimethylation (right panel) at the cebpa promoter in 3T3-L1 preadipocytes, without affecting the levels of those modifications at the promoters of control genes myod or actb. B, lsd1 knockdown decreases the induction of H3K4 trimethylation at the cebpa promoter in 3T3-L1 cells at D2. Values are the mean ± S.D. (error bars) of three experiments performed in duplicate. *, p < 0.05.