TABLE 1.
Cell-cycle-related genes affected by mDomino deletion
DNA microarray analysis of OHT-treated (+OHT) or untreated (−) mDomfl/fl;CreER MEFs were performed as described under “Experimental Procedures.” Among the 93 genes whose expression was reduced to <45% by OHT treatment (supplemental Table 1), genes that are characterized as “cell cycle” are listed.
| Gene symbol | -fold change | +OHT | (−) | p value | Accession number |
|---|---|---|---|---|---|
| E2f2 | 3.5 | 30 | 107 | 7.33E-05 | BB543028 |
| Mybl2 | 3.2 | 208 | 666 | 2.42E-04 | NM_008652 |
| Cenpf | 3.2 | 97 | 310 | 1.02E-02 | BB667318 |
| Psrc1 | 3.0 | 288 | 878 | 4.66E-04 | NM_019976 |
| Fbxo5 | 3.0 | 618 | 1851 | 7.31E-05 | AK011820 |
| E2f7 | 2.7 | 557 | 1517 | 3.98E-03 | BG069355 |
| Cdc6 | 2.7 | 564 | 1531 | 4.25E-05 | NM_011799 |
| Ccna2 | 2.6 | 2615 | 6868 | 2.04E-03 | X75483 |
| Ccnf | 2.6 | 144 | 378 | 3.59E-03 | BB089717 |
| Rbl1 | 2.6 | 178 | 465 | 2.64E-04 | U27178 |
| E2f8 | 2.6 | 336 | 876 | 2.80E-05 | BM247465 |
| Rcc1 | 2.6 | 470 | 1213 | 5.99E-06 | NM_133878 |
| 2810433K01Rik | 2.5 | 581 | 1461 | 2.32E-04 | NM_025581 |
| Mapk12 | 2.5 | 134 | 336 | 6.35E-04 | BC021640 |
| Cdca3 | 2.5 | 1732 | 4277 | 1.52E-03 | BI081061 |
| Uhrf1 | 2.4 | 192 | 470 | 6.75E-03 | BB702754 |
| Suv39h2 | 2.4 | 353 | 854 | 7.45E-04 | NM_022724 |
| Plk1 | 2.4 | 742 | 1787 | 3.42E-05 | NM_011121 |
| Rassf1 | 2.4 | 83 | 198 | 2.07E-03 | BB385028 |
| Cdc25a | 2.4 | 590 | 1405 | 1.46E-02 | C76119 |
| Nek2 | 2.4 | 339 | 802 | 3.80E-04 | NM_010892 |
| Skp2 | 2.3 | 221 | 518 | 1.43E-02 | AV259620 |
| Sgol1 | 2.3 | 314 | 732 | 3.92E-03 | BB410537 |
| Incenp | 2.3 | 87 | 201 | 2.06E-04 | AV301185 |
| Mcm3 | 2.3 | 234 | 531 | 1.02E-03 | BI658327 |
| Cdc20 | 2.2 | 2367 | 5311 | 3.80E-03 | NM_023223 |
| Ncapg2 | 2.2 | 1610 | 3593 | 1.26E-03 | NM_133762 |