Table 4.

The influence of greater depressive symptoms on cognitive performance in multiple domains

Cognitive Domain	Tests Included	Univariate		Parsimonious*		Multivariable**
		β coefficient	p-value	β coefficient	p-value	β coefficient	p-value
Executive Function	Trails B	−0.37	0.02	−0.33	0.01	−0.30	0.03
Psychomotor Speed and Processing	Trails A; Digit Symbol Coding; Block Design	−0.27	0.03	−0.25	0.02	−0.24	0.02
Memory	Delayed Recall; Recognition	−0.17	0.2	−0.17	0.2	−0.21	0.08

Greater depressive symptoms are considered to be CES-D scores ≥16; cognitive domains were quantified using z-scores. Coefficients represent the effect of having a CES-D score of ≥16 versus < 16 on cognitive performance. A negative coefficient is consistent with worse performance.

^*Parsimonious models adjust for age, education, and sex.

^**For the executive function cognitive domain, full multivariable models additionally adjust for cause of ESRD, race, and peripheral vascular disease; for Psychomotor Speed and Processing, multivariable models additionally adjust for race, Kt/V, and stroke; and for memory, multivariable models additionally adjust for race, stroke and peripheral vascular disease.

Abbreviation: CES-D, Center for Epidemiological Studies Depression Scale