FIG. 1.

Flow bioreactor. (A) Polysulfone housing. (B) Schematic illustration of a flow system that directs flow exclusively through collagen gel tissue. Gas exchange with 5% CO₂/95% air occurs via a syringe filter port attached to the medium reservoir. (C) Example of the resulting collagen gel after 7 days of culture, with the circular area marking the center region of the gel that is exposed to fluid flow. The holes on the edges resulted from the pins and constrained the gel to prevent inward radial contraction. Color images available online at www.liebertonline.com/ten.