Table 3.
Human Mesenchymal Stromal Cell Viability (%) Immediately After Infusion Through Various Catheters at Clinically Relevant Flow Rates
| 60 mL/h | 120 mL/h | 240 mL/h | 500 mL/h | |
|---|---|---|---|---|
| 20-gauge | 98.1 ± 0.06 | 98.2 ± 0.09 | 98.0 ± 0.19 | 98.0 ± 0 |
| 25-gauge | 98.1 ± 0.06 | 97.6 ± 0.07a | 97.9 ± 0.07 | 98.2 ± 0.03 |
| 30-gauge | 98.0 ± 0.09 | 97.4 ± 0.06a | 97.6 ± 0.07 | 95.0 ± 0.25a |
| SL-10 | 94.8 ± 0.43a | 94.0 ± 0.09a | 97.5 ± 0.19 | 97.3 ± 0.09a |
Control samples of MSCs had a viability of 98.1 ± 0.14. Although a statistically significant decrease in cell viability is seen with the 30-gauge catheter and SL-10 microcatheter, the difference fails to reach clinical significance.
a
Indicates statistical significance compared to control sample (ANOVA with Tukey–Kramer post hoc p < 0.05).
MSC, mesenchymal stromal cell.