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Comparison of force generated by ACh in bioengineered tissue and native longitudinal tissue. Force generation in response to ACh was significantly attenuated in magnitude and time by preincubation with VIP or in the absence of extracellular calcium. The accompanying table summarizes the mean values of force generated by the native tissue as well as the bioengineered tissue in response to 1 μM ACh under different conditions of treatment (*p < 0.05, **p < 0.001).
