Table 1. SNPs within the NEMP genes that included significant association with time to AIDS-1987 CDC definition [30].
gene | entrez | chr | score | rs | pos | loc | MAF | No. SNPs | test | model | OR/RH | p unadjusted | pGT | pST |
PECI | 10455 | 6 | 90.5 | rs629362 | 4066830 | intron | 0.31 | 15 | DCA | A | 1.7 | 6.52×10−6 | 0.04 | 0.39 |
rs853416 | 4058046 | −2880 5′ | 0.32 | 15 | DCA | A | 1.6 | 3.25×10−5 | 0.18 | 1 | ||||
rs633290 | 4059787 | −1139 5′ | 0.31 | 15 | DCA | A | 1.6 | 1.66×10−5 | 0.09 | 1 | ||||
rs584585 | 4063788 | intron | 0.31 | 15 | DCA | A | 1.6 | 1.00×10−5 | 0.05 | 0.60 | ||||
rs659025 | 4064050 | intron | 0.31 | 15 | DCA | A | 1.6 | 6.12×10−5 | 0.33 | 1 | ||||
rs7744628 | 4064995 | intron | 0.31 | 15 | DCA | A | 1.6 | 2.15×10−5 | 0.12 | 1 | ||||
rs9503922 | 4066332 | intron | 0.26 | 15 | DCA | A | 1.6 | 9.52×10−5 | 0.52 | 1 | ||||
rs659305 | 4070654 | intron | 0.31 | 15 | DCA | A | 1.6 | 1.96×10−5 | 0.11 | 1 | ||||
rs660560 | 4070940 | intron | 0.31 | 15 | DCA | A | 1.6 | 2.15×10−5 | 0.12 | 1 | ||||
rs661404 | 4071096 | intron | 0.40 | 15 | DCA | A | 1.5 | 6.40×10−5 | 0.35 | 0.35 | ||||
ACSM4 | 341392 | 12 | 75 | rs7961991 | 7371395 | intron | 0.16 | 4 | PH | R | Und | 3.59×10−6 | 0.02 | 0.22 |
rs7137120 | 7346864 | −1331 5′ | 0.16 | 4 | PH | R | Und | 8.84×10−6 | 0.05 | 0.53 |
Results are from proportional hazards (PH) models or dichotomous categorical analyses (DCA). Chr = chromosome. Score is the haplotype coverage generated by Tagger with the number of SNPs shown for that gene (SNPs) [29]. Pos = the position from HapMap Project, and build 36. loc = location relative to the gene. MAF = Minor allele frequency. R = recessive genetic Model, A = additive genetic model. RH = relative hazard. If the analysis was a DCA, or categorical test, this equates to the Odds Ratio (OR). Und = undefined, which means that there were no cases that succumbed to disease and therefore the value is not statistical calculable. p GT is the p-value corrected for 904 genes and six tests. p ST is the p-value corrected for the number of SNPs and the six tests (see methods).