Figure 5. Morphometric analysis of lesions in irradiated carotid arteries (A–D) and aortic arches (E-H) of ApoE^−/− mice treated with control chow (n = 10), NCX 4016 (60 mg/kg/day) (n = 11), low dose (30 mg/kg/day) (n = 11) or high dose ASA containing chow (300 mg/kg/day) (n = 8) for 30 weeks.

Bar graphs show the mean number of total (A, E), initial (macrophage rich, without a thick fibrous cap) (B, F) and advanced (well-defined, necrotic/lipid core or thick fibrous cap) (D, H) lesions per animal. Total plaque area is shown in C and G. Data represents group means ± SEM. * Indicates significant differences between high dose ASA and control chow (p<0.05 by Mann-Whitney U test).