Table 2. Semi-quantitative analysis of thrombotic features in unirradiated and irradiated carotid arteries of ApoE−/− mice treated with control chow, NCX 4016 (60 mg/kg/day), low dose ASA (30 mg/kg/day) or high dose ASA (300 mg/kg/day) for 30 weeks.
Treatment | Granulocytes | Fe/Macr, Ery/Macr | Fibrin |
0 Gy | |||
Control chow | 4/9 | 4/9 | 0/9 |
NCX 4016 chow | 2/9 | 4/9 | 2/9 |
ASA high chow | 8/12 | 5/12 | 1/12 |
14 Gy | |||
Control chow | 8/10 | 10/10* | 6/10* |
NCX 4016 chow | 6/11 | 9/11 | 6/11 |
ASA high chow | 6/8 | 6/8 | 3/8 |
ASA low chow | 11/11 | 10/11 | 5/11 |
*p<0.05 compared with unirradiated mice with the same chow.