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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Cancer Res. 2010 Jun 22;70(14):5901–5911. doi: 10.1158/0008-5472.CAN-10-0192

Figure. 6. The growth of A146T KRAS mutant xenografts was MEK-dependent.

Figure. 6

A. Treatment of mice bearing established LS1034 xenografts with a single oral dose of PD0325901 (25 mg/kg) resulted in downregulation of pERK and cyclin D1 expression at 6 hours and upregulation of p27 at 24 hours. B. Mice with established LS1034 (A146T KRAS) xenografts were treated with PD0325901 (25 mg/kg 5x/week × 3 weeks) or vehicle only as control. (C). Mice were treated with 10 mg/kg of cetuximab or vehicle only as control twice weekly for three weeks.