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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Reprod Sci. 2010 Aug 16;17(10):955–962. doi: 10.1177/1933719110376092

Figure 1.

Figure 1

Cortisol production in fetal adrenal cortical cells (FACs) from control and LTH ovine fetuses as described in the Methods section. A) untreated basal, or treated with sodium nitroprusside (SNP, 1mM), NOS substrate (L-arginine (L-Arg), 2mM) or the NOS inhibitor L-NAME (1mM) B) treated with ACTH (10nM) or pre-treated with sodium nitroprusside (SNP, 1mM), NOS substrate (L-arginine, 2mM) or the NOS inhibitor L-NAME (1mM) followed by ACTH treatment as described in the Methods section. C) Cortisol data normalized to % change from ACTH treatment alone. (n=6 for control and n=7 for LTH). LTH indicates long-term hypoxia; L-NAME, nitro-L-arginine methyl ester; NOS, nitric oxide synthase; ACTH, adrenocorticotropic hormone.