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. 2010 May 10;38(17):5774–5783. doi: 10.1093/nar/gkq336

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Cycle of RNA-dependent biosynthesis of Gln in Archaea. (1) GatDE (orange) associates with ND-GluRS (lime). (2) ND-GluRS:GatDE binary complex binds tRNA^Gln (silver-blue) to form the ternary complex. (3) In the transamidosome (ND-GluRS:GatDE:tRNA^Gln), ND-GluRS glutamylates tRNA^Gln. (4) ND-GluRS dissociates from the complex allowing the 3′ CCA-end of the tRNA to flip into the GatDE kinase active site. (5) GatDE transamidates the tRNA-bound Glu to Gln. (6) Gln-tRNA^Gln is released from GatDE. For clarity only one GatDE monomer is shown.