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. 2010 May 11;38(17):5718–5734. doi: 10.1093/nar/gkq212

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Global transcriptional profiling of MEF genetic models to decipher comprehensive Nrf2-dependent transcriptional targets. (A) Scheme depicts definitions for classification of Nrf2 target genes as inducible and/or basally regulated by Nrf2. Basal targets: differentially expressed genes between WT versus Nrf2^−/− MEFs; Inducible targets: differentially expressed genes between Keap1^−/− versus WT MEFs; and Common targets: genes satisfying both the former comparison criteria. (B) The panel represents the overlap of differentially expressed genes across experiments. The orange circle represents genes that were downregulated in Nrf2^−/− MEFs compared with WT (basal targets) while the blue circle shows the genes upregulated in Keap1^−/− MEFs compared with WT (inducible targets). (C) The panel represents the overlap between the microarray datasets and the ChIP-Seq dataset and intersections represent the genes common in the two datasets to identify Nrf2 direct (basal, inducible and common) transcriptional targets.