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. 2010 May 10;38(17):5681–5691. doi: 10.1093/nar/gkq339

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Metnase promotes DNA replication after release from replication stress. (A) Log phase HEK-293 cells expressing normal or low levels of Metnase were incubated with 10 µM BrdU for 30 min and average percentages (±SD) of BrdU⁺ cells are shown for two determinations per strain. (B) HEK-293 control and Metnase knockdown cells were treated with 5 mM HU for 3 h and released into medium with 10 µM BrdU. Average fold increases (±SD) in the percentage of BrdU⁺ cells relative to untreated cells (no HU, no BrdU) are plotted for three independent experiments per cell line. *P = 0.042, **P = 0.0047. (C) BrdU incorporation after HU release from HEK-293T control and Metnase overexpression cells as in panel B, except cells were treated with HU for 18 h; *P ≤ 0.03.