Skip to main content
. 2010 May 6;38(17):5657–5671. doi: 10.1093/nar/gkq346

Figure 2.

Figure 2.

Box plots showing DNA methylation changes for hypo-methylated CpG sites on chromosome X are different in CdLS. (A) DNA methylation levels of X-linked hypo-methylated CpG sites have significantly increased in CdLS as compared to autosomal hypo-methylated CpG sites. Twenty-two controls and 22 severely affected CdLS probands with NIPBL mutations were included. (B) DNA methylation levels of X-linked hypo-methylated CpG sites have significantly increased in female CdLS probands but decreased in male CdLS probands as compared with methylation changes of the autosomal CpG sites. Twenty-two controls and 22 severely affected CdLS probands with NIPBL mutations were included, and females (11 controls and 11 probands) and males (11 controls and 11 probands) were analyzed separately. The label of Y-axis is defined as ‘CdLS-Control’ = Log2 (β/1 – β)CdLS – Log2 (β/1 – β)Control, indicating the alteration of methylation levels between CdLS and controls.