Figure 5.

Cohesin preferentially binds to CpG sites at promoter regions with low levels of DNA methylation. Very little cohesin binds to hyper-methylated promoters regardless of the distance to TSSs. Log₂(β/1 – β) > 0 was defined as hyper-methylation, Log₂(β/1–β) < −2 was defined as hypo-methylation, −2 <Log₂(β/1–β) < 0 was defined as medium methylation. Cohesin binding signal was quantified from previous ChIP–chip study and log-transformed before the analysis.