Table 1.

Specific histone modification markers and repetitive genomic sequences are enriched in chromatin regions harboring differentially methylated CpGs in CdLS

	Hyper_M	Hypo_M
Histone modification markers	H2A_H4R3me2	H2A_Z
	H3K27me1, H3K27me2	H3K27me3
	H3K36me1	H3K4me2, H3K4me3
		H3K9me1, H3K9me3
		H3R2me1, H3R2me2
		H4K20me1, H4K20me3
		H3K79me3
Repetitive sequences	LINE	repClass_Low_complexity
	SINE	repFamily_Low_complexity
	L2

EpiGRAPH analysis was performed on 361 1-kb DNA fragments surrounding differentially hyper-methylated CpGs and 563 1-kb fragments surrounding differentially hypo-methylated CpGs in CdLS.

Hyper_M: chromatin region with differential hyper-methylation in CdLS; Hypo_M: chromatin region with differential hypo-methylation in CdLS.