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. Author manuscript; available in PMC: 2010 Sep 22.
Published in final edited form as: Tetrahedron. 2009 Jan 3;65(1):17–49. doi: 10.1016/j.tet.2008.09.083

Table 8.

One-pot preparation of α-aminophosphonopeptides 82a-n.

graphic file with name nihms-111580-f0012.jpg
Compound R R' R” Yield (%) ratioa
82a Ph Bn Bn 85 80 : 20
82b Ph Bn HO2CCH2 79 40 : 60
82c Ph Bn -(CH2)3- 82 90 : 10
82d Ph Bn Me 83 34 : 66
82e Pr Bn Me 88 20 : 80
82f Pr Bn HO2CCH2 86 n.d.
82g Pr Bn Bn 92 n.d.
82h Bu Bn i-Pr 80 40 : 60
82i Bu Me Bn 71 n.d.
82j Ph Me Bn 53 n.d.
82k Pr Me Bn 65 n.d.
82l Bu H Bn 88 63 : 37
82m i-PrC6H4 Bn -(CH2)3- 75 20 : 80
82n i-PrC6H4 Bn Me 70 44 : 56
a

Stereochemistry was not assigned (n.d. = not determined).