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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cancer Res. 2009 Dec 22;70(1):181–191. doi: 10.1158/0008-5472.CAN-09-2331

Figure 2. OTX2 gain and overexpression are specific to medulloblastoma subgroups.

Figure 2

A subset of the primary medulloblastomas (n=81) analyzed in Figure 1 were classified into four molecular subgroups based upon gene expression signatures obtained from exon arrays. (A) Focal gain of OTX2 (designated in red) is limited to Group C and D medulloblastomas. The minimal region of gain (~10.5 kb) is boxed. (B) OTX2 mRNA overexpression is highest in Group C and D tumors, as well as those expressing a signature of Wnt pathway activation.