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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cancer Res. 2009 Dec 22;70(1):181–191. doi: 10.1158/0008-5472.CAN-09-2331

Figure 3. Interphase FISH of OTX2 in primary medulloblastoma showing that OTX2 copy number gain is associated with tumor anaplasia and poor patient survival.

Figure 3

(A) Increased OTX2 copy number is seen in primary medulloblastoma tumors with anaplastic features. The Y axis is the ratio of the mean copy number of OTX2 to the control chromosome 14 probe in each cell of each sample. (B) Kaplan-Meier survival analysis of patients stratified by mean OTX2 copy number. (C) Kaplan-Meier survival analysis of patients stratified by age.