Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Mortality
RCT	22 term neonates with asphyxia In review	Death 2/11 (18%) with allopurinol (40 mg/kg) 6/11 (55%) with no drug treatment	RR 0.73 95% CI 0.26 to 2.09		Not significant
RCT	22 term neonates with asphyxia In review	Rates of death or developmental delay (method of assessment not reported) 4/11 (36%) with allopurinol (40 mg/kg) 7/11 (64%) with no drug treatment	RR 0.57 95% CI 0.23 to 1.41		Not significant
RCT	32 term neonates with severe asphyxia	Death 13/17 (77%) with allopurinol (iv 40 mg/kg; 2 doses) 10/15 (67%) with placebo	RR 1.15 95% CI 0.74 to 1.79		Not significant
RCT	60 term neonates with mild, moderate, or severe asphyxia	Death 3/30 (10%) with allopurinol (40 mg/kg/day for 3 days) 3/30 (10%) with placebo	RR 1.00 95% CI 0.22 to 4.56		Not significant