Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptoms of barotrauma
RCT 3-armed trial	150 adults	Proportion of people with symptoms of barotrauma (ear pain, blockage, hearing loss, dizziness/vertigo, and tinnitus; assessed by post-flight questionnaire) 14/41 (34%) with pseudoephedrine 120 mg 29/41 (71%) with placebo	RR 0.48 95% CI 0.29 to 0.67	Moderate effect size	pseudoephedrine
RCT	190 adults	Proportion of people reporting ear pain (assessed by post-flight questionnaire) 25/96 (26%) with pseudoephedrine 120 mg 43/94 (46%) with placebo	P = 0.007	Effect size not calculated	pseudoephedrine
RCT	190 adults	Proportion of people reporting hearing loss (assessed by post-flight questionnaire) 20/96 (21%) with pseudoephedrine 120 mg 38/94 (40%) with placebo	P = 0.006	Effect size not calculated	pseudoephedrine