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. Author manuscript; available in PMC: 2010 Sep 22.
Published in final edited form as: Physiol Rev. 2010 Jul;90(3):1165–1194. doi: 10.1152/physrev.00061.2009

TABLE 1.

Modes of cell death

Cell Death Mode Morphology Inhibitor
Apoptosis Cell shrinkage Caspase inhibitor
Blocks within organelles
Nucleus fragmentation
Cell fragmentation
Necrosis Cellular swelling Necrostatin-1
Blebs devoid of organelles
Moderate chromatin condensation
Rupture of plasma membrane
Autophagy Cytoplasmic vacuolization 3-Methyladenine
Double membrane vacuoles
No chromatin condensation