Table 2.
Characteristics of patients included in the reproducibility study of cardiac CT scans, comparability study of EBT vs. MDCT cardiac CT scans, and validation study of cardiac vs. full-lung CT scans.
| Reproducibility Study (n = 119) | Comparability Study (n=10) | Validation Study (n = 42) | |
|---|---|---|---|
| Age, years, mean ± SD | 58.9±9.1 | 63.8±9.9 | 62.3±10.7 |
| Male, % | 42.0 | 60 | 57.1 |
| Race/Ethnicity, % | |||
| Caucasian | 31.1 | 60 | 14.3 |
| African-American | 37.8 | 20 | 76.2 |
| Hispanic | 21.9 | 20 | 9.5 |
| Chinese | 9.2 | 0 | 0 |
| Smoking Status, % | |||
| Never | 37.3 | 20 | 51.2 |
| Former | 37.3 | 60 | 39.0 |
| Current | 25.4 | 20 | 9.8 |
| Pack-years among ever smokers, mean ± SD | 21.6±23.2 | 15.7±17.3 | 25.9±32.6 |
| Height, cm, mean ± SD | 167±10.2 | 169±10.1 | 169±9.6 |
| Weight >220 lbs, % | 19.3 | 10 | 23.8 |
| BMI, kg/m2, mean ± SD | 29.5±5.8 | 27.2±3.7 | 30.1±5.7 |
| FVC %predicted, mean ± SD | 96.9±15.5 | 95.1±15.6 | 88.7±15.8 |
| FEV1 %predicted, mean ± SD | 94.4 ± 15.1 | 89.6±18.2 | 85.9 ±18.3 |
| FEV1/FVC %, mean ± SD | 75.3 ± 6.6 | 71.0±8.3 | 73.8 ± 9.6 |
| Airflow obstruction,* % | 5.4 | 30 | 12.5 |
| CT % emphysema-910 HU,† median (interquartile range) | 13.6 (5.88, 25.2) | 10.9 (6.94, 18.5) | 18.4 (8.23, 28.9) |
| CT alpha-910 HU,† median (interquartile range) | 1.25 (1.01, 1.50) | 1.45 (1.26, 1.61) | 1.27 (0.96, 1.58) |
| Apical-basilar difference in %emphysema-910 HU,† median (interquartile range) | 0.08 (-4.04, 3.26) | -3.27 (-6.58, -1.00) | 0.98 (-1.10, 6.00) |
| Apical-basilar difference in alpha-910 HU,† median (interquartile range) | 0.14 (-0.02, 0.29) | 0.11 (0.07, 0.13) | 0.04 (-0.14, 0.24) |
*
Defined as pre-bronchodilator FEV1/FVC ratio<0.7 and FEV1<80% of predicted
†
Measured from CT scan with greater air volume in Reproducibility Study, MDCT scan in Comparability Study, and full-lung scan in Validation Study, all at -910 HU.