Table 2. Strains in the Ctgf allelic series.

Ctgf genotype	Allele	Ctgf mRNA Expression
KO/KO	del/del	0%
Lo/KO	c-fos-3′/del	30%
+/KO	WT/del	50%
Lo/Lo	c-fos-3′/c-fos-3′	60%
Lo/+	c-fos-3′/WT	85%
+/+ (WT)	WT/WT	100%
Hi/+ inducible	bGH-3′/WT	360%
Hi/+ embryos	bGH-3′/WT	930%

Ctgf expression levels are relative to WT. A single WT allele expresses 50% (2×50% = 100%). Each copy of the Ctgf Lo allele expresses about 30% of WT (Lo/+ = 30%+50%≈85%). Each copy of the Ctgf Hi allele expresses about 300% to 860% of WT. Abbreviations: KO is knockout, del is exon 3–5 deletion, and 3′ is 3′UTR.