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. 2010 Sep 22;5(9):e12878. doi: 10.1371/journal.pone.0012878

Figure 5. Structure activity relationship of EGCG.

Figure 5

(A) Cell based reporter assay was used to test the effect of EGCG analogs (2 µM) on RIG-I, TLR3, TLR4, TLR9, IPS-1, R-C, and R-CH. The effect of 10 µM of these compounds was tested on RIG-I and IPS-1. The numbers correspond to mean percent activity in comparison to DMSO treated sample (taken as 100%). Standard deviation is given in parenthesis. TLR3, 4 & 9 assays used NF-κB-luciferase as reporter plasmid and all others were performed with IFN-β luciferase as reporter plasmid. (B) Analysis of EGCG analogs on shR9 dependent RIG-I ATPase activity. Each compound was tested at 0.5 and 1 µM. Clemizole was used as a control compound. The data are shown as a mean +/− standard deviation.