Figure 8. A model depicting RIG-I activation of signal transduction and the potential site of action of EGCG.

Different domains of RIG-I depicted are, CARD (N-terminal dual CARD domains), Hel (helicase domain), RD (C-terminal Regulatory domain). Different numbers correspond to potential site of action of EGCG. IPS-1 is the adapter of RIG-I and is localized on the mitochondrial membrane (depicted as double line). More details can be found in the text.