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. 2010 May;27(5):789–801. doi: 10.1089/neu.2008.0809

FIG. 1.

FIG. 1.

BD Matrigel and ECM gel, but not methylcellulose, improve GFP-SC numbers over cell:medium suspensions (A–D). A significant improvement in SC numbers at 12 weeks following implantation into the injured spinal cord is achieved over DMEM-F12 medium suspensions (A) when the cells are injected within ECM gel (B) or BD Matrigel (C) but not methylcellulose (D). Sections are 20-μm thick sagittal sections taken from the center of the SC graft from an animal with the overall SC survival rate closest to that of the mean for that group. SCs are labeled with GFP (green) and host astrocytes are stained for GFAP (red). Scale bar: 500 μm. (E) Stereological quantification of SC numbers post implantation shows a significant increase when laminin:collagen matrices are employed; a significant decrease was observed compared to medium controls when methylcellulose was used. Statistical significance indicated at *p < 0.05, **p < 0.01, or ***p < 0.001. Color image is available online at www.liebertonline.com/neu.