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. 2010 Jul 23;29(17):2888–2898. doi: 10.1038/emboj.2010.169

Figure 7.

Figure 7

A conserved regulatory pathway determines the accumulation of Ups1 and Ups2 in the intermembrane space, which regulate the phospholipid composition of mitochondrial membranes. Ups1 and Ups2 are unstable proteins that are degraded by the i-AAA protease Yme1 and in the case of Ups1, also by Atp23. Binding of Mdm35 stabilizes Ups1 and Ups2 against proteolysis and ensures accumulation of both proteins in the intermembrane space. Both Ups1 and Ups2 have been found to be membrane associated (Tamura et al, 2009; Osman et al, 2009a) but are shown as soluble proteins in the IMS for simplicity. See text for details. IM, mitochondrial inner membrane; IMS, mitochondrial intermembrane space; OM, mitochondrial outer membrane.