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. 2010 Apr 22;118(9):1217–1222. doi: 10.1289/ehp.0901257

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Neonatal exposure to BPA alters ovarian histology in adult female rats. Ovaries from control and BPA-treated animals were stained with hematoxylin and eosin and viewed under a light microscope. Abbreviations: AF, antral follicles; Atr F, atretic follicles; CL, corpus luteum; GC, granulosa cell; POF, preovulatory follicles. (A) Number of ovarian structures by type of structure. (B) Total number of structures by treatment. (C–F) Representative slides from each treatment. (C) Control. (D) BPA50. (E) BPA500. (F) A higher magnification of (E), showing a cystic follicle in detail; the inset shows the thin granulosa layer and nondetectable theca in the follicle.

*p < 0.05 compared with control, by structure type in (A) and by treatment in (B), as determined by ANOVA (n = 5).