Figure 1.

The yeast sporulation network constructed from literature. The bold links are regulatory interactions found by UMMI. Ime2, Rim4, and Ndt80 are early meiotic genes and are thus denoted with an "E" in parentheses. They are repressed by Rpd3 and activated by Gcn5 like other EMGs. These edges are not shown for the sake of clarity. The DNA-binding proteins are denoted with an asterisk before their names. ^a The phosphorylation of Ime2 to Ndt80 is still hypothetical. However, removal of this edge does not affect our results (see Additional file 1). ^b Rim4 acts as an RNA binding protein to stabilize Ime2 mRNA (see Additional file 1).