Table 4.
Most differentially expressed genes between responders and non-responders to radiotherapy
| Twenty most up-regulated genes in responders to radiotherapy | ||||
|---|---|---|---|---|
| Probe set | Gene symbol | Description | FC | p-value |
| 211538_s_at | HSPA2 | Heat shock 70 kDa protein 2 | 3.4 | < 10-4 |
| 209687_at | CXCL12 | Chemokine ligand 12 (SDF1) | 2.6 | 0.001 |
| 209480_at | HLA-DQB1 | MHC complex, class II, DQ beta 1 | 2.5 | 0.023 |
| 221900_at | COL8A2 | Collagen, type VIII, alpha 2 | 2.5 | 0.004 |
| 226818_at | MPEG1 | Macrophage expressed gene 1 | 2.4 | < 10-4 |
| 219759_at | ERAP2 | Endoplasmic reticulum aminopeptidase 2 | 2.3 | 0.019 |
| 220146_at | TLR7 | Toll-like receptor 7 | 2.3 | 0.002 |
| 222881_at | HPSE | Heparanase | 2.2 | < 10-4 |
| 239270_at | PLCXD3 | Phosphatidylinositol-specific Phospholipase C, × domain containing 3 | 2.2 | 0.001 |
| 218858_at | DEPDC6 | DEP domain containing 6 | 2.2 | 0.001 |
| 209343_at | EFHD1 | EF-hand domain family, D1 | 2.2 | 0.004 |
| 205034_at | CCNE2 | Cyclin E2 | 2.2 | 0.004 |
| 223170_at | TMEM98 | Transmembrane protein 98 | 2.2 | 0.012 |
| 203184_at | FBN2 | Fibrillin 2 | 2.2 | 0.020 |
| 1557395_at | LOC255130 | 2.2 | 0.035 | |
| 204466_s_at | SNCA | Synuclein, alpha | 2.1 | 0.017 |
| 228598_at | DPP10 | Dipeptidyl-peptidase 10 | 2.1 | 0.023 |
| 1567628_at | CD74 | CD74 molecule, MHC complex | 2.1 | 0.006 |
| 219750_at | TMEM144 | Transmembrane protein 144 | 2.1 | 0.04 |
| 228376_at | GGTA1 | Glycoprotein, alpha-galactosyltransferase 1 | 2.1 | 0.006 |
| Twenty genes most differentially up-regulated in non-responders to radiotherapy | ||||
| 220405_at | SNTG1 | Syntrophin, gamma 1 | 3.4 | 0.001 |
| 236761_at | LHFPL3 | Lipoma HMGIC fusion partner-like 3 | 3.2 | 0.035 |
| 204913_s_at | SOX11 | SRY (sex determining region Y)-box 11 | 3.1 | 0.038 |
| 205230_at | RPH3A | Rabphilin 3A homolog (mouse) | 2.8 | 0.014 |
| 202859_x_at | IL8 | Interleukin 8 | 2.8 | 0.023 |
| 206201_s_at | MEOX2 | Mesenchyme homeobox 2 | 2.7 | 0.047 |
| 230498_at | MCHR1 | Melanin-concentrating hormone receptor 1 | 2.7 | 0.006 |
| 1554452_at | HIG2 | Hypoxia-inducible protein 2 | 2.7 | 0.003 |
| 206984_s_at | RIT2 | Ras-like without CAAX 2 | 2.6 | 0.023 |
| 225285_at | BCAT1 | Branched chain aminotransferase 1, cytosolic | 2.4 | < 10-4 |
| 223278_at | GJB2 | Gap junction protein, beta 2, 26kDa | 2.4 | 0.021 |
| 205358_at | GRIA2 | Glutamate receptor, ionotropic, AMPA 2 | 2.4 | 0.027 |
| 227361_at | HS3ST3B1 | Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 | 2.4 | 0.038 |
| 211527_x_at | VEGFA | Vascular endothelial growth factor A | 2.4 | 0.015 |
| 219196_at | SCG3 | Secretogranin III | 2.3 | 0.025 |
| 232099_at | PCDHB16 | Protocadherin beta 16 | 2.3 | 0.010 |
| 217562_at | FAM5C | Family with sequence similarity 5, member C | 2.3 | 0.023 |
| 214920_at | THSD7A | Thrombospondin, type I, domain containing 7A | 2.3 | 0.025 |
| 202499_s_at | SLC2A3 | Solute carrier family 2 (facilitated glucose transporter), member 3 | 2.2 | < 10-4 |
| 202912_at | ADM | Adrenomedullin | 2.2 | 0.016 |
List of the 20 genes most up-regulated and with a p-value <0.05 in responders versus non-responders and in non-responders versus responders to radiotherapy. FC: Fold change, p-value: Limma T-test p-value. Immune genes and hypoxia genes are underlined in responders and non-responders, respectively.