Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 8;30(36):12128–12137. doi: 10.1523/JNEUROSCI.2474-10.2010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 the authors 0270-6474/10/3012128-10$15.00/0

PMC Copyright notice

Figure 5. — Synergistic calcium interactions between RyR and glutamatergic synaptic transmission in AD Tg neurons. A, Pseudocolored images of relative calcium changes in representative NonTg (top), TAS/TPM (middle), and 3xTg-AD (bottom) neurons in the following conditions (from left to right): baseline (ACSF), 30 Hz synaptic stimulation (1.5 s), caffeine alone (10 mm), 30 Hz synaptic stimulation plus caffeine, and washout. B, Representative Ca²⁺ response traces after 30 Hz synaptic stimulation (voltage trace shown in top) shown as percentage over baseline, in control ACSF (left panels) and in 10 mm caffeine (right panels) for NonTg (top), 3xTg-AD (middle), and TAS/TPM (bottom) neurons. C, Bar graphs show averaged (mean ± SE) Ca²⁺ responses integrated over a 1.5 s time period of 30 Hz synaptic stimulation in control ACSF (left grouping), synaptic stimulation plus caffeine (center), and synaptic stimulation with ryanodine in the pipette (right grouping) for the NonTg, TAS/TPM, and 3xTg-AD neurons. Statistically significant differences are indicated by asterisks (one-way ANOVA, p < 0.05). *Significantly different from NonTg within treatment group; **significantly different from synaptic stimulation in ACSF within transgenic strain.