Table 3.
Main anthropometric, clinical, functional, and radiological variables in patients with COPD, stratified according to the BODE index and gender (mean ± SD or proportion).
| BODE 0 1 2 | BODE 3 4 | BODE 5 6 | BODE 7 8 9 10 | Differences within females | Differences within males | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Females | Males | p value | Females | Males | p value | Females | Males | p value | Females | Males | p value | Females | Males | |
| BODE Index | 1.1 ± 0.8 | 1.3 ± 0.8 | 0.014 | 3.5 ± 0.5 | 3.4 ± 0.5 | 0.088 | 5.4 ± 0.5 | 5.4 ± 0.5 | 0.874 | 7.5 ± 0.8 | 7.5 ± 0.7 | 0.658 | < 0.001 | < 0.001 |
| Clinical data | ||||||||||||||
| Age (years) | 62.3 ± 7.0 | 63.5 ± 7.3 | 0.008 | 62.8 ± 6.8 | 63.6 ± 7.2 | 0.132 | 62.3 ± 7.0 | 64.9 ± 6.6 | 0.001 | 63.9 ± 7.1 | 63.9 ± 7.0 | 0.949 | 0.362 | 0.090 |
| Pack years (n) | 39.7 ± 20.5 | 51.0 ± 29.2 | < 0.001 | 43.3 ± 22.2 | 50.6 ± 27.7 | 0.001 | 43.6 ± 22.9 | 55.7 ± 28.0 | < 0.001 | 41.9 ± 17.8 | 57.8 ± 31.8 | < 0.001 | 0.186 | 0.002 |
| BMI (Kg/m2) | 26.4 ± 5.0 | 27.3 ± 4.5 | 0.001 | 26.1 ± 6.1 | 26.6 ± 5.5 | 0.162 | 26.4 ± 8.1 | 26.3 ± 6.1 | 0.596 | 23.8 ± 7.0 | 25.9 ± 6.0 | 0.017 | 0.006 | < 0.001 |
| FFMI (Kg/m2) | 15.9 ± 2.7 | 18.4 ± 2.3 | < 0.001 | 15.5 ± 2.3 | 17.9 ± 2.7 | < 0.001 | 15.8 ± 3.0 | 17.6 ± 2.9 | < 0.001 | 14.9 ± 3.0 | 17.1 ± 2.4 | < 0.001 | 0.001 | < 0.001 |
| MMRC score | 0.9 ± 0.7 | 0.9 ± 0.7 | 0.893 | 1.8 ± 0.7 | 1.8 ± 0.8 | 0.443 | 2.6 ± 0.9 | 2.5 ± 0.8 | 0.619 | 3.1 ± 0.8 | 3.3 ± 0.6 | 0.051 | < 0.001 | < 0.001 |
| SGRQ total score | 38.0 ± 17.1 | 38.0 ± 18.7 | 0.961 | 54.1 ± 15.5 | 53.0 ± 16.1 | 0.541 | 63.1 ± 16.1 | 62.6 ± 14.6 | 0.809 | 70.2 ± 12.9 | 72.5 ± 13.2 | 0.352 | < 0.001 | < 0.001 |
| Exacerbations a(n) | 0.6 ± 1.0 | 0.5 ± 0.9 | 0.006 | 1.1 ± 1.4 | 0.9 ± 1.3 | 0.152 | 1.5 ± 1.4 | 1.2 ± 1.5 | 0.006 | 1.6 ± 1.7 | 1.1 ± 1.2 | 0.276 | < 0.001 | < 0.001 |
| Physiology | ||||||||||||||
| Post-BD FEV1 (% ref). | 62.1 ± 9.8 | 58.8 ± 11.7 | < 0.001 | 46.6 ± 12.2 | 42.8 ± 12.1 | 0.001 | 37.9 ± 10.8 | 34.4 ± 9.4 | 0.003 | 32.6 ± 8.8 | 29.1 ± 8.5 | 0.022 | < 0.001 | < 0.001 |
| Post-BD FEV/FVC (%) | 51.9 ± 9.1 | 49.7 ± 10.0 | 0.003 | 44.5 ± 10.4 | 41.9 ± 11.1 | 0.004 | 40.0 ± 10.6 | 36.9 ± 9.9 | 0.009 | 39.7 ± 9.9 | 35.0 ± 8.6 | 0.003 | < 0.001 | < 0.001 |
| FEV1 reversibility (%) | 10.5 ± 12.5 | 11.3 ± 13.6 | 0.319 | 9.7 ± 14.8 | 12.2 ± 15.2 | 0.020 | 10.5 ± 14.4 | 10.6 ± 12.3 | 0.687 | 7.8 ± 12.8 | 8.3 ± 14.0 | 0.787 | 0.300 | 0.072 |
| 6MWD (metres) | 432 ± 93 | 447 ± 94 | 0.013 | 349 ± 91 | 379 ± 95 | < 0.001 | 269 ± 88 | 289 ± 84 | 0.015 | 164 ± 74 | 185 ± 67 | 0.084 | < 0.001 | < 0.001 |
| Imaging | ||||||||||||||
| LAA | 11.3 ± 9.9 | 13.8 ± 9.7 | < 0.001 | 17.7 ± 11.1 | 19.0 ± 11.5 | 0.244 | 22.6 ± 13.2 | 23.6 ± 13.1 | 0.616 | 25.5 ± 13.6 | 28.9 ± 12.6 | 0.171 | < 0.001 | < 0.001 |
aIn the year prior to study entry.