Table 4.
Main anthropometric, clinical, functional, and radiological variables in patients with COPD, stratified according to disease severity (GOLD) and the presence or absence of chronic bronchitis (mean ± SD or proportion).
| GOLD II | GOLD III | GOLD IV | Comparing | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | p-value | Yes | No | p-value | Yes | No | p-value | GOLD Stage within Yes | GOLD Stage within No | |
| Clinical data | |||||||||||
| N | 294 | 660 | 337 | 574 | 118 | 178 | |||||
| Age (years) | 62.6 (7.5) | 63.8 (7.0) | 0.018 | 63.2 (7.4) | 64.0 (6.7) | 0.183 | 62.0 (7.6) | 62.7 (6.6) | 0.698 | 0.335 | 0.043 |
| Male (%) | 193 (66%) | 381 (58%) | 0.021 | 258 (77%) | 360 (63%) | < 0.001 | 96 (81%) | 123 (69%) | 0.019 | < 0.001 | 0.014 |
| Pack-years | 49.0 (29.3) | 47.7 (28.1) | 0.423 | 50.3 (27.3) | 48.5 (24.6) | 0.450 | 50.1 (28.9) | 48.7 (26.1) | 0.870 | 0.578 | 0.172 |
| Current smokers (%) | 153 (52%) | 207 (31%) | < 0.001 | 154 (46%) | 187 (33%) | < 0.001 | 44 (37%) | 38 (21%) | 0.003 | 0.021 | 0.015 |
| BMI (kg/m2) | 26.7 (5.4) | 27.7 (5.8) | 0.007 | 26.0 (5.5) | 26.3 (5.6) | 0.415 | 24.3 (5.4) | 25.4 (5.9) | 0.140 | < 0.001 | < 0.001 |
| FFMI (kg/m2) | 17.4 (2.7) | 17.6 (3.0) | 0.339 | 17.0 (2.5) | 17.0 (2.9) | 0.387 | 16.4 (2.6) | 16.4 (2.6) | 0.986 | 0.008 | < 0.001 |
| mMRC Score | 1.5 (1.0) | 1.3 (1.0) | 0.002 | 1.8 (1.0) | 1.8 (1.1) | 0.861 | 2.4 (1.0) | 2.3 (1.0) | 0.739 | < 0.001 | < 0.001 |
| SGRQ-C total score | 50.3 (18.8) | 38.9 (20.5) | < 0.001 | 58.8 (17.6) | 51.2 (18.2) | < 0.001 | 65.0 (16.5) | 59.4 (15.2) | 0.010 | < 0.001 | < 0.001 |
| Number of exacerbationsa | 0.7 (1.1) | 0.6 (1.0) | 0.132 | 1.0 (1.2) | 1.0 (1.4) | 0.253 | 1.2 (1.6) | 1.2 (1.3) | 0.436 | < 0.001 | < 0.001 |
| Physiology | |||||||||||
| FEV1 % Predicted | 62.3 (8.8) | 63.5 (8.2) | 0.030 | 40.3 (5.7) | 40.3 (5.9) | 0.957 | 25.1 (3.4) | 24.5 (3.8) | 0.322 | < 0.001 | < 0.001 |
| FEV1/FVC (%) | 52.3 (9.0) | 53.0 (8.7) | 0.358 | 41.0 (9.4) | 40.1 (8.6) | 0.199 | 32.2 (8.6) | 31.9 (6.8) | 0.985 | < 0.001 | < 0.001 |
| FEV1 reversibility (%) | 10.8 (12.4) | 11.4 (12.8) | 0.222 | 11.2 (15.1) | 10.9 (14.3) | 0.826 | 8.2 (15.3) | 7.8 (12.9) | 0.866 | 0.070 | 0.001 |
| 6MWD (metres) | 397 (118) | 409 (109) | 0.059 | 352 (113) | 358 (121) | 0.289 | 306 (125) | 278 (115) | 0.106 | < 0.001 | < 0.001 |
| BODE Index | 1.8 (1.4) | 1.5 (1.3) | < 0.001 | 4.0 (1.6) | 3.9 (1.7) | 0.430 | 5.7 (1.7) | 5.8 (1.5) | 0.730 | < 0.001 | < 0.001 |
| Imaging | |||||||||||
| Emphysema (%) | 12.3 (10.3) | 12.0 (9.2) | 0.854 | 19.1 (11.7) | 20.5 (11.5) | 0.082 | 28.3 (13.4) | 28.1 (12.1) | 0.822 | < 0.001 | < 0.001 |
| Bronchiectasis (%) | 3 (1%) | 10 (2%) | 0.644 | 22 (8%) | 19 (4%) | 0.006 | 7 (7%) | 13 (8%) | 0.797 | 0.001 | < 0.001 |
aIn the year prior to study entry.