Body mass and total fat and lean mass in macrophage inflammatory protein (MIP)-1α+/+, MIP-1α+/−, and MIP-1α−/− mice. Mice were either started on Western diet (WD; solid lines) at wk 8 or kept on chow diet (CD; dashed lines). Data shown are for the 16-wk study period: body mass for male (A) and female (B) mice, total fat mass measured by NMR for male (C) and female (D) mice, and total lean mass measured by NMR in male (E) and female (F) mice. Open square, MIP-1α+/+; gray circle, MIP-1α+/−; closed triangle, MIP-1α−/−. Nos. of animals per group were as follows: CD-fed males: 4 MIP-1α+/+, 15 MIP-1α+/−, 6 MIP-1α−/−; WD-fed males: 15 MIP-1α+/+, 32 MIP-1α+/−, 23 MIP-1α−/−; CD-fed females: 6 CD MIP-1α+/+, 15 CD MIP-1α+/−, 6 CD MIP-1α−/−; WD-fed females: 20 MIP-1α+/+, 23 CD MIP-1α+/−, 24 CD MIP-1α−/−.