Fig. 4.

Breeding OVE to C57BL6 reduces mesangial matrix expansion and glomerular volume. Representative periodic acid-Schiff (PAS) staining of FVB (A), OVE/C57F1 (B), and OVE (C) kidneys is shown. D: PAS staining scored by a blind observer, as described in materials and methods. There were significant differences among all groups (*P < 0.001). E: average glomerular volumes calculated as described in materials and methods. Scores and volumes were obtained from at least 45 randomly selected glomeruli obtained from 3 mice/group. All groups were significantly different (*P < 0.05).