Fig. 6.
Effect of NO synthesis inhibition on CNO in the interstitium, vasa recta endothelium, capillary endothelium, and tubular epithelium in each region. Results are displayed for case C; CNO values in cases A, B, and C are nearly indistinguishable. Shown are concentrations under baseline conditions (black bars), assuming inhibition of tubular epithelial NO synthesis only (white bars, “zero epi”), and assuming inhibition of vascular endothelial NO synthesis only (grey bars, “zero endo”). Results suggest that vascular NO synthesis acts to limit Na+ reabsorption across mTAL, whereas tubular NO synthesis does not significantly affect vascular tone.